Iron metabolism disorder and multiple sclerosis: a comprehensive analysis.

ABSTRACT:

Background

Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system. Currently, the pathological mechanisms of MS are not fully understood, but research has suggested that iron metabolism disorder may be associated with the onset and clinical manifestations of MS.

Methods and materials

The study utilized publicly available databases and bioinformatics techniques for gene expression data analysis, including differential expression analysis, weighted correlation network analysis, gene enrichment analysis, and construction of logistic regression models. Subsequently, Mendelian randomization was used to assess the causal relationship between different iron metabolism markers and MS.

Results

This study identified IREB2, LAMP2, I

SUBMITTER: Tang C 

PROVIDER: S-EPMC11000231 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature