Cardiac markers in left-sided breast cancer patients receiving adjuvant radiotherapy: a prospective study.

ABSTRACT:

Objectives

To investigate the association between radiotherapy (RT) and cardiac biomarkers in women with left-sided breast cancer.

Methods

This prospective observational study recruited patients with stage I-III left-sided breast cancer without coronary heart disease who required adjuvant RT. High-sensitivity troponin I(hsTnI), N-terminal pro-brain natriuretic peptide(NT-proBNP), and high-sensitivity C-reactive protein(hsCRP) levels were measured pre-RT, immediately after RT, and 3 months post-RT. Cardiac-sparing RT techniques were utilized (Field-in-Field IMRT/VMAT ± voluntary deep inspiration breath-hold). Statistical analyses were performed using non-parametric tests and multivariable quantile regression (QR).

Results

One hundred five patients completed the study,

SUBMITTER: Chufal K 

PROVIDER: S-EPMC11000277 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature