Origin, evolution, and diversification of inositol 1,4,5-trisphosphate 3-kinases in plants and animals.

ABSTRACT:

Background

In Eukaryotes, inositol polyphosphates (InsPs) represent a large family of secondary messengers and play crucial roes in various cellular processes. InsPs are synthesized through a series of pohophorylation reactions catalyzed by various InsP kinases in a sequential manner. Inositol 1,4,5-trisphosphate 3-kinase (IP3 3-kinase/IP3K), one member of InsP kinase, plays important regulation roles in InsPs metabolism by specifically phosphorylating inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5-tetrakisphosphate (IP4) in animal cells. IP3Ks were widespread in fungi, plants and animals. However, its evolutionary history and patterns have not been examined systematically.

Results

A total of 104 and 31 IP3K orthologues were identified across 57 plant genomes and 13

SUBMITTER: Xiong T 

PROVIDER: S-EPMC11000326 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature