STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke.

ABSTRACT: Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption of the surviving neuronal network and related brain function. Unfortunately, there is currently no effective target for suppressing the microglia-mediated synapse engulfment. Stimulator of interferon genes (STING) is an important participant in innate immune response. In the brain, microglia are the primary cell type that mediate immune response after brain insult. The intimate relationship between STING and microglia-mediated neuroinflammation has been gradually established. However, whether STING affects other functions of microglia remains elusive. In this study, we found that STING

SUBMITTER: Wu C 

PROVIDER: S-EPMC11000342 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature