Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism.

ABSTRACT:

Background

The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as a biomarker for chronic kidney disease (CKD) is controversial. Additionally, the main pathways through which Klotho exerts its effects on CKD remain unclear. Therefore, we used bioinformatics and clinical data analysis to determine its role in CKD.

Results

We analyzed the transcriptomic and clinical data from the Nephroseq v5 database and found that the Klotho gene was mainly expressed in the tubulointerstitium, and its expression was significantly positively correlated with estimated glomerular filtration rate (eGFR) and negatively correlated with blood urea nitrogen (BUN) in CKD. We further found that Klotho gene expression was mainly negatively associated with inflamma

SUBMITTER: Liu J 

PROVIDER: S-EPMC11000353 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature