HSPA4 upregulation induces immune evasion via ALKBH5/CD58 axis in gastric cancer.

ABSTRACT:

Introduction

Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. Recently, targeted therapies including PD1 (programmed cell death 1) antibodies have been used in advanced GC patients. However, identifying new biomarker for immunotherapy is still urgently needed. The objective of this study is to unveil the immune evasion mechanism of GC cells and identify new biomarkers for immune checkpoint blockade therapy in patients with GC.

Methods

Coimmunoprecipitation and meRIP were performed to investigate the mechanism of immune evasion of GC cells. Cocuture system was established to evaluate the cytotoxicity of cocultured CD8⁺ T cells. The clinical significance of HSPA4 upregulation was analyzed by multiplex fluorescent immunohistochemist

SUBMITTER: Suo D 

PROVIDER: S-EPMC11000359 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature