Gut Microbiome and Metabolic and Immune Indices in Males with or without Evidence of Metabolic Dysregulation.

ABSTRACT:

Background

The contributions of the gut microbiota to obesity and metabolic disease represent a potentially modifiable factor that may explain variation in risk between individuals. This study aimed to explore relationships among microbial composition and imputed functional attributes, a range of soluble metabolic and immune indices, and gene expression markers in males with or without evidence of metabolic dysregulation (MetDys).

Methods

This case-control study included healthy males (n=15; 41.9±11.7 years; body mass index [BMI], 22.9±1.2 kg/m²) and males with evidence of MetDys (n=14; 46.6±10.0 years; BMI, 35.1±3.3 kg/m²) who provided blood and faecal samples for assessment of a range of metabolic and immune markers and microbial composition using 16S

SUBMITTER: Hatton-Jones KM 

PROVIDER: S-EPMC11000514 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature