Design of Oscillatory Networks through Post-Translational Control of Network Components.

ABSTRACT: Many essential functions in biological systems, including cell cycle progression and circadian rhythm regulation, are governed by the periodic behaviors of specific molecules. These periodic behaviors arise from the precise arrangement of components in biomolecular networks that generate oscillatory output signals. The dynamic properties of individual components of these networks, such as maturation delays and degradation rates, often play a key role in determining the network's oscillatory behavior. In this study, we explored the post-translational modulation of network components as a means to generate genetic circuits with oscillatory behaviors and perturb the oscillation features. Specifically, we used the NanoDeg platform-A bifunctional molecule consisting of a target-specific nanobod

SUBMITTER: Jayanthi BEK 

PROVIDER: S-EPMC11000592 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature