Comparison of T cells mediated immunity and side effects of mRNA vaccine and conventional COVID-19 vaccines administrated in Jordan.

ABSTRACT: Various COVID-19 vaccines can affect the immune system. Discrepancies have been noted in immune system characteristics, such as T-lymphocyte levels, between vaccinated and non-vaccinated individuals. This study investigates the variations in immune responses among the four administered COVID-19 vaccines, influencing factors, and clinical outcomes in Jordan. A total of 350 adults, who were at least two doses vaccinated, were interviewed and blood samples were collected for subsequent laboratory analyses. The study involved the quantification of T-cells specifically targeting anti-SARS CoV-2 using Flow cytometry analysis. BNT162b2 (Pfizer) recipients displayed significantly higher CD3⁺/CD4⁺ T-helper cell responses (90.84%, 87.46% - 94.22%) compared to non-Pfizer-BioNTec

SUBMITTER: Jaber HM 

PROVIDER: S-EPMC11000609 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature