Ontology highlight
ABSTRACT:
SUBMITTER: Pant A
PROVIDER: S-EPMC11000615 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Pant Ayush A Hwa-Lin Bergsneider Brandon B Srivastava Siddhartha S Kim Timothy T Jain Aanchal A Bom Sadhana S Shah Pavan P Kannapadi Nivedha N Patel Kisha K Choi John J Cho Kwang Bog KB Verma Rohit R Yu-Ju Wu Caren C Brem Henry H Tyler Betty B Pardoll Drew M DM Jackson Christina C Lim Michael M
Oncoimmunology 20240404 1
Immunotherapy has revolutionized the treatment of cancers. Reinvigorating lymphocytes with checkpoint blockade has become a cornerstone of immunotherapy for multiple tumor types, but the treatment of glioblastoma has not yet shown clinical efficacy. A major hurdle to treat GBM with checkpoint blockade is the high degree of myeloid-mediated immunosuppression in brain tumors that limits CD8 T-cell activity. A potential strategy to improve anti-tumor efficacy against glioma is to use myeloid-modula ...[more]