Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia.

ABSTRACT:

Background

Expansion of genome-wide association studies across population groups is needed to improve our understanding of shared and unique genetic contributions to breast cancer. We performed association and replication studies guided by a priori linkage findings from African ancestry (AA) relative pairs.

Methods

We performed fixed-effect inverse-variance weighted meta-analysis under three significant AA breast cancer linkage peaks (3q26-27, 12q22-23, and 16q21-22) in 9241 AA cases and 10 193 AA controls. We examined associations with overall breast cancer as well as estrogen receptor (ER)-positive and negative subtypes (193,132 SNPs). We replicated associations in the African-ancestry Breast Cancer Genetic Consortium (AABCG).

Results

In AA women, we identified two

SUBMITTER: Ochs-Balcom HM 

PROVIDER: S-EPMC11000665 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature