Urinary CD4 + T Cells Predict Renal Relapse in ANCA-Associated Vasculitis.

ABSTRACT:

Significance statement

Early identification of patients at risk of renal flares in ANCA vasculitis is crucial. However, current clinical parameters have limitations in predicting renal relapse accurately. This study investigated the use of urinary CD4 + T lymphocytes as a predictive biomarker for renal flares in ANCA vasculitis. This study, including urine samples from 102 patients, found that the presence of urinary CD4 + T cells was a robust predictor of renal relapse within a 6-month time frame, with a sensitivity of 60% and a specificity of 97.8%. The diagnostic accuracy of urinary CD4 + T cells exceeded that of ANCA titers, proteinuria, and hematuria. Monitoring urinary CD4 + T lymphocytes could help assess the risk of future renal relapse, enabling early preventive measures a

SUBMITTER: Prskalo L 

PROVIDER: S-EPMC11000730 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature