Atrial cardiomyocytes contribute to the inflammatory status associated with atrial fibrillation in right heart disease.

ABSTRACT:

Aims

Right heart disease (RHD), characterized by right ventricular (RV) and atrial (RA) hypertrophy, and cardiomyocytes' (CM) dysfunctions have been described to be associated with the incidence of atrial fibrillation (AF). Right heart disease and AF have in common, an inflammatory status, but the mechanisms relating RHD, inflammation, and AF remain unclear. We hypothesized that right heart disease generates electrophysiological and morphological remodelling affecting the CM, leading to atrial inflammation and increased AF susceptibility.

Methods and results

Pulmonary artery banding (PAB) was surgically performed (except for sham) on male Wistar rats (225-275 g) to provoke an RHD. Twenty-one days (D21) post-surgery, all rats underwent echocardiography and electrophysiologica

SUBMITTER: Le Quilliec E 

PROVIDER: S-EPMC11000822 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature