Peeling back the many layers of competitive exclusion.

ABSTRACT: Baby chicks administered a fecal transplant from adult chickens are resistant to Salmonella colonization by competitive exclusion. A two-pronged approach was used to investigate the mechanism of this process. First, Salmonella response to an exclusive (Salmonella competitive exclusion product, Aviguard^®) or permissive microbial community (chicken cecal contents from colonized birds containing 7.85 Log₁₀Salmonella genomes/gram) was assessed ex vivo using a S. typhimurium reporter strain with fluorescent YFP and CFP gene fusions to rrn and hilA operon, respectively. Second, cecal transcriptome analysis was used to assess the cecal communities' response to Salmonella in chickens with low (≤5.85 Log₁₀

SUBMITTER: Maurer JJ 

PROVIDER: S-EPMC11000858 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature