WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.

ABSTRACT:

Background and objectives

Cardiac injury plays a critical role in contributing to the mortality associated with sepsis, a condition marked by various forms of programmed cell deaths. Previous studies hinted at the WW domain-containing E3 ubiquitin protein ligase 2 (WWP2) involving in heart failure and endothelial injury. However, the precise implications of WWP2 in sepsis-induced cardiac injury, along with the underlying mechanisms, remain enigmatic.

Methods

Sepsis induced cardiac injury were constructed by intraperitoneal injection of lipopolysaccharide. To discover the function of WWP2 during this process, we designed and performed loss/gain-of-function studies with cardiac-specific vectors and WWP2 knockout mice. Combination experiments were performed to investigate the r

SUBMITTER: Li Z 

PROVIDER: S-EPMC11000860 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature