Alterations of the gut microbiota in the lupus nephritis: a systematic review.

ABSTRACT:

Background

Emerging evidence suggests that gut microbiota dysbiosis may play a critical role in the development of lupus nephritis (LN). However, the specific characteristics of the gut microbiota in individuals with LN have not been fully clarified.

Methods

The PubMed, Web of Science, and Embase databases were systematically searched for clinical and animal studies related to the relationship between LN and gut microbiota from inception until October 1, 2023. A semiquantitative analysis was used to assess the changes in gut microbial profiles.

Results

A total of 15 clinical studies were selected for analysis, which included 138 LN patients, 441 systemic lupus erythematosus patients, and 1526 healthy controls (HCs). Five different types of LN mouse models were include

SUBMITTER: Wang A 

PROVIDER: S-EPMC11001323 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature