Cysteine hyperoxidation rewires communication pathways in the nucleosome and destabilizes the dyad.

ABSTRACT: Gene activity is tightly controlled by reversible chemical modifications called epigenetic marks, which are of various types and modulate gene accessibility without affecting the DNA sequence. Despite an increasing body of evidence demonstrating the role of oxidative-type modifications of histones in gene expression regulation, there remains a complete absence of structural data at the atomistic level to understand the molecular mechanisms behind their regulatory action. Owing to μs time-scale MD simulations and protein communication networks analysis, we describe the impact of histone H3 hyperoxidation (i.e., S-sulfonylation) on the nucleosome core particle dynamics. Our results reveal the atomic-scale details of the intrinsic structural networks within the canonical histone core and thei

SUBMITTER: Karami Y 

PROVIDER: S-EPMC11001638 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature