Role of plasma EBV-DNA load and EBER status on newly diagnosed peripheral T-cell lymphoma.

ABSTRACT:

Purpose

To explore the prognostic and therapeutic role of Epstein-Barr Virus (EBV) on peripheral T-cell lymphoma (PTCL).

Methods

Totally 262 newly diagnosed PTCL patients who were hospitalized from January 2014 to December 2022 were retrospectively enrolled. Molecular analysis included 31 eligible patients. EBV-encoded RNA (EBER) presence in tumor tissue and EBV DNA levels in patients at baseline (DNA1) and after 4 cycles of chemotherapy (DNA4) were assessed.

Results

Our findings revealed that the EBER-positive cohort exhibited significant differences compared to counterparts in overall survival (OS, P = 0.047) and progression-free survival (PFS, P = 0.009). Both DNA1 and DNA4 were significantly associated with inferior OS. Multivariate analysis demonstrated that DNA4

SUBMITTER: Chen J 

PROVIDER: S-EPMC11001675 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature