Anti-toxoplasma activity and DNA-binding of copper(II) and zinc(II) coordination compounds with 5-nitroimidazole-based ligands.

ABSTRACT: Tetrahedral copper(II) and zinc(II) coordination compounds from 5-nitroimidazole derivatives, viz. 1-(2-chloroethyl)-2-methyl-5-nitroimidazole (cenz) and ornidazole 1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole (onz), were synthesized and spectroscopically characterized. Their molecular structures were determined by X-ray diffraction studies. The complexes [Cu(onz)₂X₂], [Zn(onz)₂X₂], [Cu(cenz)₂X₂] and [Zn(cenz)₂X₂] (X^- = Cl, Br), are stable in solution and exhibit positive LogD_7.4 values that are in the range for molecules capable of crossing the cell membrane via passive difussion. Their biological activity against Toxoplasma gondi was investigated, and IC₅₀ an

SUBMITTER: Navarro-Penaloza R 

PROVIDER: S-EPMC11001709 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature