Influence of fluid accumulation on major adverse kidney events in critically ill patients - an observational cohort study.

ABSTRACT:

Background

Fluid accumulation (FA) is known to be associated with acute kidney injury (AKI) during intensive care unit (ICU) stay but data on mid-term renal outcome is scarce. The aim of this study was to investigate the association between FA at ICU day 3 and major adverse kidney events in the first 30 days after ICU admission (MAKE30).

Methods

Retrospective, single-center cohort study including adult ICU patients with sufficient data to compute FA and MAKE30. We defined FA as a positive cumulative fluid balance greater than 5% of bodyweight. The association between FA and MAKE30, including its sub-components, as well as the serum creatinine trajectories during ICU stay were examined. In addition, we performed a sensitivity analysis for the stage of AKI and the presence of

SUBMITTER: Hofer DM 

PROVIDER: S-EPMC11001812 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature