MORITS: An improved method to predict peptides from heterologous proteins that are recognized by the same T-cell receptor.

ABSTRACT: Antigen-specific priming of T cells results in the activation of T cells that exert effector functions by interaction of their T-cell receptor (TCR) with the corresponding self-MHC molecule presenting a peptide on the surface of a target cell. Such antigen-specific T cells potentially can also interact with peptide-MHC complexes that contain peptides from unrelated antigens, a phenomenon that often is referred to as heterologous immunity. For example, some individuals that were pre-immunized against an allergen, could subsequently mount better anti-viral T-cell responses than non-allergic individuals. So far only few peptide pairs that experimentally have been shown to provoke heterologous immunity were  identified, and available prediction tools that can identify potential candidates are

SUBMITTER: Bruhn M 

PROVIDER: S-EPMC11002005 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature