Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour.

ABSTRACT:

Introduction

Imprinted genes are expressed from one parental allele as a consequence of epigenetic processes initiated in the germline. Consequently, their ability to influence phenotype depends on their parent-of-origin. Recent research suggests that the sex of the individual expressing the imprinted gene is also important. We have previously reported that genetically wildtype (WT) dams carrying and caring for pups mutant for PEG3 exhibit anxiety-like behaviours and their mutant pups show a reduction in ultrasonic vocalisation when separated from their mothers. Sex-specificity was not examined.

Methods

WT female mice were mated with WT, heterozygous Peg3^-/+ or homozygous Peg3^-/- studs to generate all WT (control), 50:50 mixed or 10

SUBMITTER: Tyson HR 

PROVIDER: S-EPMC11002209 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature