Depression and hepatobiliary diseases: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

More and more evidence suggests a close association between depression and hepatobiliary diseases, but its causal relationship is not yet clear.

Method

Using genome-wide association studies (GWAS) to summarize data, independent genetic variations associated with depression were selected as instrumental variables. Firstly, we designed a univariate Mendelian randomization (UVMR) analysis with two samples and simultaneously conducted reverse validation to evaluate the potential bidirectional causal relationship between depression and various hepatobiliary diseases. Secondly, we conducted a multivariate Mendelian randomization (MVMR) analysis on diseases closely related to depression, exploring the mediating effects of waist to hip ratio, hypertension, and daytime nap

SUBMITTER: Kong Y 

PROVIDER: S-EPMC11002219 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature