Microbiota profiling reveals alteration of gut microbial neurotransmitters in a mouse model of autism-associated 16p11.2 microduplication.

ABSTRACT: The gut-brain axis is evident in modulating neuropsychiatric diseases including autism spectrum disorder (ASD). Chromosomal 16p11.2 microduplication 16p11.2^dp/+ is among the most prevalent genetic copy number variations (CNV) linked with ASD. However, the implications of gut microbiota status underlying the development of ASD-like impairments induced by 16p11.2^dp/+ remains unclear. To address this, we initially investigated a mouse model of 16p11.2^dp/+, which exhibits social novelty deficit and repetitive behavior characteristic of ASD. Subsequently, we conducted a comparative analysis of the gut microbial community and metabolomic profiles between 16p11.2^dp/+ and their wild-type counterparts using 16S rRNA sequencing and liquid chromatography-ma

SUBMITTER: Fu Z 

PROVIDER: S-EPMC11002229 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature