Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function.

ABSTRACT:

Introduction

The immune systems of both the mother and the newborn face significant challenges during birth. Proper immune regulation after birth is essential for the survival of neonates. Numerous studies have demonstrated that the neonatal immune system is relatively immature, particularly in its adaptive arm, placing the primary responsibility for immune surveillance on innate immunity.

Methods

Given the significant role of neutrophils in protecting the neonate after birth, we conducted a study investigating the properties of neutrophils in newborn cord blood using various methodological approaches.

Results

Our findings demonstrate the presence of immature low-density neutrophils in the cord blood, which are likely responsible for the observed elevated expression o

SUBMITTER: Mikova E 

PROVIDER: S-EPMC11002259 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature