Spatiotemporal development of the neuronal accumulation of amyloid precursor protein and the amyloid plaque formation in the brain of 3xTg-AD mice.

ABSTRACT: The amyloid plaque is a hallmark of Alzheimer's disease. The accumulation of the amyloid precursor protein (APP) in the neuronal structure is assumed to lead to amyloid plaque formation through the excessive production of β-amyloid protein. To study the relationship between the neuronal accumulation of APP and amyloid plaque formation, we histologically analyzed their development in the different brain regions in 3xTg-AD mice, which express Swedish mutated APP (APP_SWE) in the neurons. Observation throughout the brain revealed APP_SWE-positive somata in the broad regions. Quantitative model analysis showed that the somatic accumulation of APP_SWE developed firstly in the hippocampus from a very early age (<1 month) and proceeded slower in the isocortex. In lin

SUBMITTER: Ono M 

PROVIDER: S-EPMC11002285 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature