PROJECT PREVENT: a randomized controlled trial of preoperative vaginal metronidazole to decrease patient issues and infections after hysterectomy.

ABSTRACT:

Objectives

To evaluate if vaginal metronidazole for 5 days before hysterectomy decreases postoperative infections and patient issues.

Design

This randomized trial compared vaginal metronidazole for 5 days before a scheduled hysterectomy to no intervention. Sample size calculation was based on a 20% difference in issues and infection (30% incidence and 10% in the intervention arm) with 80% power and an alpha error of 0.05 and indicated 62 subjects needed in each arm.

Setting

Outpatient gynecology clinics at a single academic institution.

Participants

154 subjects were screened for eligibility between July 2020 and September 2022. 133 underwent hysterectomy including 68 subjects (51.1%) randomized to the metronidazole and 65 (48.9%) controls. Overall, the populat

SUBMITTER: Pradhan T 

PROVIDER: S-EPMC11002362 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature