The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population.

ABSTRACT:

Objective

The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are inflammatory disorders with ANCA autoantibodies recognising either proteinase 3 (PR3-AAV) or myeloperoxidase (MPO-AAV). PR3-AAV and MPO-AAV have been associated with distinct loci in the human leucocyte antigen (HLA) region. While the association between MPO-AAV and HLA has been well characterised in East Asian populations where MPO-AAV is more common, studies in populations of European descent are limited. The aim of this study was to thoroughly characterise associations to the HLA region in Scandinavian patients with PR3-AAV as well as MPO-AAV.

Methods

Genotypes of single-nucleotide polymorphisms (SNPs) located in the HLA region were extracted from a targeted exome-sequencing dataset

SUBMITTER: Lundtoft C 

PROVIDER: S-EPMC11002376 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature