Tumor-derived mesenchymal progenitor cell-related genes in the regulation of breast cancer proliferation.

ABSTRACT:

Background

Breast cancer (BC) is one of the most common malignancies worldwide, and its development is affected in various ways by the tumor microenvironment (TME). Tumor-derived mesenchymal progenitor cells (MPCs), as the most important components of the TME, participate in the proliferation and metastasis of BC in several ways. In this study, we aimed to characterize the genes associated with tumor-derived MPCs and determine their effects on BC cells.

Methods

Tumor-derived MPCs and normal breast tissue-derived mesenchymal stem cells (MSCs) were isolated from tissues specimens of patients with BC. We conducted culture and passage, phenotype identification, proliferation and migration detection, inflammatory factor release detection, and other experiments on isolated MPCs fr

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11002474 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature