Additional local therapy before disease progression for EGFR-mutated advanced lung cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

International guidelines recommend the use of local therapy (LT) to limited progression in patients with epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC). However, the use of LT before disease progression has not been extensively analyzed. This meta-analysis evaluates the efficacy and safety of administering additional LT in conjunction with first-line EGFR-tyrosine kinase inhibitors (TKIs) before disease progression in patients with EGFR-mutated advanced NSCLC.

Methods

We systematically searched PubMed, Embase, and the Cochrane Library for studies published up until May 31, 2023. The LT group consisted of patients who received first-line EGFR-TKIs in conjunction with additional LT, while the TKI group comprised participa

SUBMITTER: Seong H 

PROVIDER: S-EPMC11002518 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature