Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock.

ABSTRACT:

Objective

Recent clinical guidelines for sepsis management emphasize immediate antibiotic initiation for suspected septic shock. Though hypotension is a high-risk marker of sepsis severity, prior studies have not considered the precise timing of hypotension in relation to antibiotic initiation and how clinical characteristics and outcomes may differ. Our objective was to evaluate antibiotic initiation in relation to hypotension to characterize differences in sepsis presentation and outcomes in patients with suspected septic shock.

Methods

Adults presenting to the emergency department (ED) June 2012-December 2018 diagnosed with sepsis (Sepsis-III electronic health record [EHR] criteria) and hypotension (non-resolving for ≥30 min, systolic blood pressure <90 mmHg) within 24 h.

SUBMITTER: Prasad PA 

PROVIDER: S-EPMC11002635 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature