Cardiometabolic disease, cognitive decline, and brain structure in middle and older age.

ABSTRACT:

Introduction

The presence of multiple cardiometabolic diseases (CMDs) has been linked to increased dementia risk, but the combined influence of CMDs on cognition and brain structure across the life course is unclear.

Methods

In the UK Biobank, 46,562 dementia-free participants completed a cognitive test battery at baseline and a follow-up visit 9 years later, at which point 39,306 also underwent brain magnetic resonance imaging. CMDs (diabetes, heart disease, and stroke) were ascertained from medical records. Data were analyzed using age-stratified (middle age [< 60] versus older [≥ 60]) mixed-effects models and linear regression.

Results

A higher number of CMDs was associated with significantly steeper global cognitive decline in older (β = -0.008; 95% confide

SUBMITTER: Dove A 

PROVIDER: S-EPMC11002777 | biostudies-literature | 2024 Apr-Jun

REPOSITORIES: biostudies-literature