Quantitative susceptibility mapping in multiple sclerosis: A systematic review and meta-analysis.

ABSTRACT:

Background

Quantitative susceptibility mapping (QSM) is a quantitative measure based on magnetic resonance imaging sensitive to iron and myelin content. This makes QSM a promising non-invasive tool for multiple sclerosis (MS) in research and clinical practice.

Objective

We performed a systematic review and meta-analysis on the use of QSM in MS.

Methods

Our review was prospectively registered on PROSPERO (CRD42022309563). We searched five databases for studies published between inception and 30th April 2023. We identified 83 English peer-reviewed studies that applied QSM images on MS cohorts. Fifty-five included studies had at least one of the following outcome measures: deep grey matter QSM values in MS, either compared to healthy controls (HC) (k = 13) or correlated

SUBMITTER: Voon CC 

PROVIDER: S-EPMC11002889 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature