Bacillus coagulans regulates gut microbiota and ameliorates the alcoholic-associated liver disease in mice.

ABSTRACT:

Introduction

Alcoholic-associated liver diseases (ALD) are now widespread issues worldwide. Alcoholic-induced chronic dysbiosis of the gut microbiota is one of the factors in the pathophysiology of ALD.

Methods

In this work, we employed a chronic-binge ethanol feeding mice model, as described in a previous report.

Results

Our findings demonstrate that hepatic inflammatory injury damage and accumulation of fat can be effectively reduced in mice with ALD by altering the gut microbiota utilizing Bacillus coagulans. Treatment with B. coagulans significantly modulates the levels of TNF-α, IL-1β, and IL-22 cytokines while maintaining tight junction proteins and mucin protein expressions to support intestinal barrier function restoration. Treatment with B. c

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11002907 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature