Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation.

ABSTRACT:

Background

Erythroid and myeloid differentiation disorders are commonly occurred in leukemia. Given that the relationship between erythroid and myeloid lineages is still unclear. To find the co-regulators in erythroid and myeloid differentiation might help to find new target for therapy of myeloid leukemia. In hematopoiesis, ALA (alpha lipoic acid) is reported to inhibit neutrophil lineage determination by targeting transcription factor ELK1 in granulocyte-monocyte progenitors via splicing factor SF3B1. However, further exploration is needed to determine whether ELK1 is a common regulatory factor for erythroid and myeloid differentiation.

Methods

In vitro culture of isolated CD34⁺, CMPs (common myeloid progenitors) and CD34⁺ CD371^- HSPCs (hem

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11003016 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature