NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological properties; however, its function in pulmonary fibrosis is yet to be established. Hence, in this investigation, it was attempted to figure out the anti-pulmonary fibrosis influences of protodioscin and its pharmacological properties related to oxidative stress.

Methods

A mouse lung fibrosis model was generated using tracheal injections of bleomycin, followed by intraperitoneal injection of different concentrations of protodioscin, and the levels of oxidative stress and fibrosis were detected in the lungs. Multiple fibroblasts were treated with TGF-β to induce t

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC11003024 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature