Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases.

ABSTRACT:

Background

Despite substantial research revealing that patients with rheumatoid arthritis (RA) have excessive morbidity and mortality of cardiovascular disease (CVD), the mechanism underlying this association has not been fully known. This study aims to systematically investigate the phenotypic and genetic correlation between RA and CVD.

Methods

Based on UK Biobank, we conducted two cohort studies to evaluate the phenotypic relationships between RA and CVD, including atrial fibrillation (AF), coronary artery disease (CAD), heart failure (HF), and stroke. Next, we used linkage disequilibrium score regression, Local Analysis of [co]Variant Association, and bivariate causal mixture model (MiXeR) methods to examine the genetic correlation and polygenic overlap between RA and CVD

SUBMITTER: Sun X 

PROVIDER: S-EPMC11003061 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature