Serum metabolism alteration behind different etiology, diagnosis, and prognosis of disorders of consciousness.

ABSTRACT:

Background

Patients with disorders of consciousness (DoC) exhibit varied revival outcomes based on different etiologies and diagnoses, the mechanisms of which remain largely unknown. The fluctuating clinical presentations in DoC pose challenges in accurately assessing consciousness levels and prognoses, often leading to misdiagnoses. There is an urgent need for a deeper understanding of the physiological changes in DoC and the development of objective diagnostic and prognostic biomarkers to improve treatment guidance.

Methods

To explore biomarkers and understand the biological processes, we conducted a comprehensive untargeted metabolomic analysis on serum samples from 48 patients with DoC. Patients were categorized based on etiology (TBI vs. non-TBI), CRS-R scores, and prog

SUBMITTER: Ge Q 

PROVIDER: S-EPMC11003070 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature