Hesperidin ameliorates H₂O₂-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.

ABSTRACT:

Background

Hesperidin is a citrus flavonoid with anti-inflammatory and antioxidant potential. However, its protective effects on bovine mammary epithelial cells (bMECs) exposed to oxidative stress have not been elucidated.

Results

In this study, we investigated the effects of hesperidin on H₂O₂-induced oxidative stress in bMECs and the underlying molecular mechanism. We found that hesperidin attenuated H₂O₂-induced cell damage by reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels, increasing catalase (CAT) activity, and improving cell proliferation and mitochondrial membrane potential. Moreover, hesperidin activated the Keap1/Nrf2/ARE signaling pathway by inducing the nuclear translocation of Nrf2 and the expre

SUBMITTER: Huang Q 

PROVIDER: S-EPMC11003082 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature