Colonization during a key developmental window reveals microbiota-dependent shifts in growth and immunity during undernutrition.

ABSTRACT:

Background

Childhood undernutrition is a major global health challenge with devastating lifelong consequences. Linear growth stunting due to undernutrition has been linked to poor health outcomes, and mothers who experience growth stunting in childhood are more likely to give birth to stunted children later in life. Based on these findings, we hypothesized that intergenerational colonization of mice with microbiota from human donors with undernutrition may recapitulate certain immune and growth changes observed in this disorder.

Results

To test this hypothesis, we developed a gnotobiotic murine model of undernutrition using microbiota from human infants with healthy or stunted growth trajectories. Intergenerational colonization with microbiota derived from children with grow

SUBMITTER: Serrano Matos YA 

PROVIDER: S-EPMC11003143 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature