Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior.

ABSTRACT:

Background

Brain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The cerebral venous system (CVS) contains approximately 70% of the total cerebral blood volume; similar to the cerebral arterial system, the CVS plays a prominent role in the maintenance of central nervous system (CNS) homeostasis. Impaired venous autoregulation, which can appear in forms such as cerebral venous congestion, may lead to metabolic abnormalities in the brain, causing severe cerebral functional defects and even chronic tinnitus. However, the role of cerebral venous congestion in the progression of tinnitus is underrecognized, and its pathophysiology is still incompletely understood. This study elucidated the specific pathogenetic role of cerebral venous c

SUBMITTER: Wei H 

PROVIDER: S-EPMC11003147 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature