Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer.

ABSTRACT:

Background

The mesenchymal subtype of colorectal cancer (CRC), associated with poor prognosis, is characterized by abundant expression of the cellular prion protein PrP^C, which represents a candidate therapeutic target. How PrP^C is induced in CRC remains elusive. This study aims to elucidate the signaling pathways governing PrP^C expression and to shed light on the gene regulatory networks linked to PrP^C.

Methods

We performed in silico analyses on diverse datasets of in vitro, ex vivo and in vivo models of mouse CRC and patient cohorts. We mined ChIPseq studies and performed promoter analysis. CRC cell lines were manipulated through genetic and pharmacological approaches. We created mice combining conditional inactivation of Apc in

SUBMITTER: Mouillet-Richard S 

PROVIDER: S-EPMC11003154 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature