Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis.

ABSTRACT:

Background

Autophagy is a lysosome-dependent degradation pathway that regulates macrophage activation, differentiation, and polarization. Autophagy related 5 (Atg5) is a key protein involved in phagocytic membrane elongation in autophagic vesicles that forms a complex with Atg12 and Atg16L1. Alterations in Atg5 are related to both acute and chronic kidney diseases in experimental models. However, the role of macrophage-expressed Atg5 in acute kidney injury remains unclear.

Methods

Using a myeloid cell-specific Atg5 knockout (MΦ atg5^-/-) mouse, we established renal ischemia/reperfusion and unilateral ureteral obstruction models to evaluate the role of macrophage Atg5 in renal macrophage migration and fibrosis.

Results

Based on changes in the serum urea nitro

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11003172 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature