Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.

ABSTRACT: Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infects up to a quarter of the world's population. Although immune responses can control Mtb infection, 5%-10% of infected individuals can progress to active TB disease (progressors). A myriad of host factors regulate disease progression in TB and a better understanding of immune correlates of protection and disease is pivotal for the development of new therapeutics. Comparison of human whole blood transcriptomic metadata with that of macaque TB progressors and Mtb-infected diversity outbred mice (DO) led to the identification of differentially regulated gene (DEG) signatures, associated with TB progression or control. The current study assessed the function of Phospholipase C epsilon (PLCƐ1), t

SUBMITTER: Gupta A 

PROVIDER: S-EPMC11003233 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature