Genome-Wide Investigation Reveals Potential Therapeutic Targets in Shigella spp.

ABSTRACT: Shigella stands as a major contributor to bacterial dysentery worldwide scale, particularly in developing countries with inadequate sanitation and hygiene. The emergence of multidrug-resistant strains exacerbates the challenge of treating Shigella infections, particularly in regions where access to healthcare and alternative antibiotics is limited. Therefore, investigations on how bacteria evade antibiotics and eventually develop resistance could open new avenues for research to develop novel therapeutics. The aim of this study was to analyze whole genome sequence (WGS) of human pathogenic Shigella spp. to elucidate the antibiotic resistance genes (ARGs) and their mechanism of resistance, gene-drug interactions, protein-protein interactions, and functional pathw

SUBMITTER: Hossain MA 

PROVIDER: S-EPMC11003385 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature