A Mild and Modular Approach to the Total Synthesis of Desferrioxamine B.

ABSTRACT: A mild and modular approach to the total synthesis of the WHO-listed essential medicine desferrioxamine B is described. Hydroxamic acid fragments were installed under mild conditions, a generalized divergent acylation procedure used to access two monomer precursors, and a transfer hydrogenation reaction used to unmask the hydroxamic acid moieties. Desferrioxamine B was generated over ten linear steps as the formate salt in 17% overall yield using standard amide coupling conditions or in 13% overall yield using microwave-assisted amide coupling conditions.

SUBMITTER: Markham TE 

PROVIDER: S-EPMC11003418 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature