Recombinant transmissible vaccines will be intrinsically contained despite the ability to superinfect.

ABSTRACT:

Introduction

Transmissible vaccines offer a novel approach to suppressing viruses in wildlife populations, with possible applications against viruses that infect humans as zoonoses - Lassa, Ebola, rabies. To ensure safety, current designs propose a recombinant vector platform in which the vector is isolated from the target wildlife population. Because using an endemic vector creates the potential for preexisting immunity to block vaccine transmission, these designs focus on vector viruses capable of superinfection, spreading throughout the host population following vaccination of few individuals.

Areas covered

We present original theoretical arguments that, regardless of its R₀ value, a recombinant vaccine using a superinfecting vector is not expected to expand it

SUBMITTER: Bull JJ 

PROVIDER: S-EPMC11003445 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature