Antiangiogenic exclusion rules in glioma trials: Historical perspectives and guidance for future trial design.

ABSTRACT:

Background

Despite the lack of proven therapies for recurrent high-grade glioma (HGG), only 8%-11% of patients with glioblastoma participate in clinical trials, partly due to stringent eligibility criteria. Prior bevacizumab treatment is a frequent exclusion criterion, due to difficulty with response assessment and concerns for rebound edema following antiangiogenic discontinuation. There are no standardized trial eligibility rules related to prior antiangiogenic use.

Methods

We reviewed ClinicalTrials.gov listings for glioma studies starting between May 2009 and July 2022 for eligibility rules related to antiangiogenics. We also reviewed the literature pertaining to bevacizumab withdrawal.

Results

Two hundred and ninety-seven studies for patients with recurrent gliom

SUBMITTER: Sener U 

PROVIDER: S-EPMC11003534 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature