CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer.

ABSTRACT:

Objectives

Regulatory T (Treg) cells regulate immunity in autoimmune diseases and cancers. However, immunotherapies that target tumor-infiltrating Treg cells often induce unwanted immune responses and tissue inflammation. Our research focussed on exploring the expression pattern of CD177 in tumor-infiltrating Treg cells with the aim of identifying a potential target that can enhance immunotherapy effectiveness.

Methods

Single-cell RNA sequencing (scRNA-seq) data and survival data were obtained from public databases. Twenty-one colorectal cancer patient samples, including fresh tumor tissues, peritumoral tissues and peripheral blood mononuclear cells (PBMCs), were analysed using flow cytometry. The transendothelial activity of CD177⁺ Treg cells was substantiated us

SUBMITTER: Ke S 

PROVIDER: S-EPMC11003710 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature