Biosynthetic potential of the sediment microbial subcommunities of an unexplored karst ecosystem and its ecological implications.

ABSTRACT: Microbial communities from various environments have been studied in the quest for new natural products with a broad range of applications in medicine and biotechnology. We employed an enrichment method and genome mining tools to examine the biosynthetic potential of microbial communities in the sediments of a coastal sinkhole within the karst ecosystem of the Yucatán Peninsula, Mexico. Our investigation led to the detection of 203 biosynthetic gene clusters (BGCs) and 55 secondary metabolites (SMs) within 35 high-quality metagenome-assembled genomes (MAGs) derived from these subcommunities. The most abundant types of BGCs were Terpene, Nonribosomal peptide-synthetase, and Type III polyketide synthase. Some of the in silico identified BGCs and SMs have been previously reported to exhibit b

SUBMITTER: Suarez-Moo P 

PROVIDER: S-EPMC11003711 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature